Prophylactic Surgery in Hereditary Breast/Ovarian Cancer Syndrome
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چکیده
Drs. Levine and Gemignani have provided a comprehensive review of the literature regarding the management of patients with hereditary breast/ovarian cancer syndrome. As noted, over 200,000 new cases of breast cancer and 25,000 new cases of ovarian cancer are estimated for 2003.[1] Only a small portion of these cases will be hereditary; however, these are the cases that may benefit from preventive measures. The potential for risk-reducing strategies in these patients has become a critical issue over the past several years. This review highlights the salient features of identifying “at-risk” patients, as well as the benefits and limitations of surgical prophylaxis.
منابع مشابه
Prophylactic surgery in hereditary breast/ovarian cancer syndrome.
The hereditary breast/ovarian cancer syndrome is responsible for approximately 5% of all breast cancers and 10% of all ovarian cancers. Although this accounts for a small portion of these diseases, much attention has been focused on this syndrome because of the abundance of research in this area. The majority of the hereditary breast/ovarian syndrome can be attributed to germ-line mutations in ...
متن کامل[Hereditary breast and ovarian cancer syndrome].
Population with hereditary breast and ovarian cancer syndrome, i.e. BRCA1/2 mutation carriers, are at higher risk of developing breast and ovarian cancer as well as other solid tumours such as pancreatic cancer, prostate cancer and melanoma. With the increasing experience, screening recommendations and preventive strategies including prophylactic surgery are being settled. Surveillance of women...
متن کاملProphylactic Surgery in Hereditary Breast/Ovarian Cancer Syndrome
Drs. Levine and Gemignani have provided a comprehensive review of the literature regarding the management of patients with hereditary breast/ovarian cancer syndrome. As noted, over 200,000 new cases of breast cancer and 25,000 new cases of ovarian cancer are estimated for 2003.[1] Only a small portion of these cases will be hereditary; however, these are the cases that may benefit from preventi...
متن کاملSociety of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions.
Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk of ovarian, tubal, and peritoneal cancers. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2, MSH6, or PMS2, associated with the Lynch/Hereditary No...
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rophylactic risk-reducing surgery has been earlier suggested effective to improve survival in individuals selected on the basis of a strong family history. Now, genetic increasing the accuracy of cancer risk estimates allows surgery to target individuals with CDH1 or BRCA1/BRCA2 mutations who are at high risk of developing gastric cancer and breast cancer respectively. Here, we discuss the rein...
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